ARACH FRIENDS
ARACHNOIDITIS SUPPORT GROUP

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NOTES
September 27-28, 2004
 
INSTITUTE OF MEDICINE
Committee on Spinal Cord Injury: Strategies in a Search for a Cure
500 5th St, NW, Keck Bldg, Room 100
Washington, DC

ARACHNOIDITIS

Introduction
Short about Arachnoiditis
DepoMedrol
Important and other Arachnoiditis Links


IOM

Institute of Medicine - IOM
Talks - IOM Conference
IOM Strategies in Search for a Cure

Living with Arachnoiditis - Letters to IOM


LIFE WITH DISABILITY

What Should I Ask My Pain Doctor
Meet our Members

Homepage

EDC
END DEPO NOW CAMPAIGN

Arachnoiditis is a debilitating condition characterized by severe stinging and burning pain along with other neurological problems. It is caused by an inflammation of the arachnoid lining - one of the 3 linings that surround the spinal cord and brain. This inflammation causes constant irritation, scarring, and binding of nerve roots and blood vessels.

ESI's: Similarly, there is growing evidence that the neurotoxic suspensions and preservatives* found in Epidural Steroid Injections can also cause Arachnoiditis, especially if the steroid's toxic compounds are accidentally injected into the spinal cord or nerve roots during the procedure. (Our recent survey indicates that finding a doctor that would promptly diagnose this error so that the appropriate countermeasures can be swiftly ordered is extremely difficult.)

3. Infection Induced
Arachnoiditis can also be caused by certain pathogens that infect the spinal cord such as meningitis and syphilis.

Treatment
There is no cure for Arachnoiditis. Treatment options are geared toward pain relief and are similar to treatments for other chronic pain conditions. Some examples include the following:

1) Pain medications such as NSAIDs, corticosteroids, anti-spasm drugs, anti-convulsants (to help with burning pain), and in some cases powerful narcotic pain relievers. Some of these medications may even be administered through and intrathecal spinal pump which, when implanted inside the body and under the skin, can administer pain medication directly into the spinal cord**.

2) Physical therapy such as hydrotherapy, massage and hot/cold therapy.

3) Transcutaneous Electrical Nerve Stimulation (TENS) - A treatment in which an electrical current is administered to specific nerves through an electrode patch placed on the skin. The mild electrical current generates heat that serves to relieve stiffness, increase blood flow, improve mobility, and hopefully relieve pain.

4) Spinal Cord Stimulator (SCS)** - A device that is also implanted inside the body that transmits an electrical signal charge directly over the spinal cord for pain relief

 

Recommendations for Spinal Cord Research Strategies

Basic Research

Strategies that promote neuronal growth and protection following injury to the nervous system, particularly the spinal cord.
Strategies that enhance restoration of function after injury to the central nervous system
Strategies that encourage repair, neural plasticity and reorganization of neural cells.
Examination of role of ion channels in nerve conduction and restoration of conduction (sodium, potassium and calcium).
Development of transplantation approaches to enhance conduction through damaged levels of spinal cord, e.g. transplantation of myelin - forming cells, growth-factor secreting cells, and neural progenitors.

Secondary Neuronal Damage

Delineation of events following trauma to the spinal cord and the underlying mechanisms causing progressive damage.
Evaluation of drugs, cell-based therapies, and other interventions that prevent or minimize secondary damage

Secondary Medical Complications

Development of improved treatment of medical complications such as: urinary tract infections, pressure sores, respiratory problems, bowel management, cardiovascular problems, sexual issues, spasticity, obesity, adjustment and depression.
Examination of the biologic and physiologic mechanisms underlying the etiology of the complications and interventions to improve function.
Evaluation of the impact and effectiveness of evidenced-based clinical practice guidelines.

Neuropathic Pain

Examination of the mechanisms underlying neuropathic pain.
Development of new therapeutic strategies for neuropathic pain.
Evaluation of the efficacy of pharmacological agents and other interventions that alleviate, reduce or eliminate neuropathic pain.

Technology

Assessment of rehabilitation engineering and other technologies to improve health and function - robotics, voice activated technology, wheelchair systems, assistive devices, environmental controls and community mobility systems.

Long Term & Aging

Development of measures of quality of life to understand impact of interventions on long-term outcomes.
Elucidation of metabolic changes associated with aging and spinal cord injury.
Identification and treatment of psychological, sexual and rehabilitation problems.

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